A Novel Facile Method of Labeling Octreotide with 18F-Fluorine
نویسندگان
چکیده
منابع مشابه
Application of a Microfluidic Droplet Mixer for [18f] Fluorine Labeling of Biomolecules for Positron Emission Tomography
The most widely used method to label biomolecules with fluorine-18 is the formation of an amide bond between a lysine residue and 4-fluorobenzoate by reaction with N-succinimidyl 4-[F]fluorobenzoate ([F]SFB). The reaction of [F]SFB with the biomolecule is usually performed in macroscopic scale, whereas the reagents are only present in microscopic amounts. Thus, it could be beneficial to carry o...
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The quantitative uptake kinetics of (2-[18F]fluoropropionyl-(D)phe1)-octreotide (I), a somatostatin (SRIF) receptor-specific tracer, was measured by PET. Conventional organ biodistribution and in vivo stabilities of the tracer as well as in vivo displacement and SRIF receptor blocking were determined. The 18F-fluorinated octreotide was compared with ([67Ga]-DFO-B-succinyl-(D)phe1)-octreotide (I...
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To label proteins with positron emitters with a half-life in the order of days, a method has been developed to label proteins with zirconium (Zr)-isotopes. Therefore, the bifunctional chelating agent desferal (Df) was coupled to albumins via a thioether bond. Labeling of the premodified proteins was easily performed by addition of these proteins to freeze-dried Zr-oxalate. This labeling was eff...
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ژورنال
عنوان ژورنال: Journal of Nuclear Medicine
سال: 2010
ISSN: 0161-5505,2159-662X
DOI: 10.2967/jnumed.109.066902